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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
EU strict laws about the health of userbinds and PubMed literature: [cited 12/12/12]

C. Other Drug-Food Interactions:

Here are the key drug-food Interactions to be aware of:

  1. Grapefruit and Grape Juice: Grapefruit can increase the levels of tadalafil by inhibiting enzymes linked with breakdown. This increase in enzyme activity may amplify side effects, such as headaches or dizziness.
  2. : Though this interaction does not significantly increase side effects, consuming aLoad of alcohol with Cialis might worsen side effects like headaches or increase heart rate in sensitive individuals.
  3. : While consuming a list ofNone of high-fat foods, consuming grapefruit or grapefruit juice with Cialis could potentially increase side effects like headaches or increase heart rate in dizzy individuals.

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Side Effects - Nausea, Vomiting, Headache, Flushing, Dizziness, Inflammation

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Cialis

Cialis is a prescription medication used to treat erectile dysfunction (ED). It is also known by its brand name Tadalafil. Cialis works by increasing blood flow to the penis, allowing for a firmer, longer-lasting erection.

Benefits of Cialis:

  • Used to treat erectile dysfunction and benign prostatic hyperplasia.
  • Also used for:
  • Cialis is also known by its brand name Tadalafil.

How to use Cialis?

Take this medication by mouth as directed by your doctor. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

If you have trouble swallowing the tablets, it is important to take it with a full glass of water. Do not take Cialis more than once per day. If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose to catch up.

Cialis side effects:

Some people may experience side effects when taking Cialis. These include:

  • Flushing or lightheadedness
  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Back pain
  • Muscle aches
  • Runny nose
  • Weakness in the limbs

If you experience any severe side effects, such as a serious allergic reaction, have an immediate call for a healthcare provider.

Who should not take Cialis?

Do not take Cialis if you:

  • Are allergic to Tadalafil or any other ingredients in Cialis
  • Have a heart condition
  • Have liver or kidney problems
  • Are allergic to Cialis or any other ingredients in Cialis

Other medicines or substances may interact with Cialis and may cause an allergic reaction, including:

  • Nitrates
  • Alpha-blockers
  • Antifungals
  • Antivirals
  • Rapid heartbeat
  • Indigestion
  • Diarrhea

If you experience any of these side effects, talk to your healthcare provider right away:

  • Rash
  • Trouble breathing
  • Difficulty in breathing

Cialis dosage:

The recommended starting dose of Cialis is 20 mg, taken orally once per day. Depending on your response, the doctor may adjust the dosage to 40 mg or even lower. Depending on your medical condition and response, the dose may be increased to 80 mg or decreased to 5 mg.

Cialis interactions:

Although there is not a known interaction between Cialis and other medicines, some people may experience an increased risk of experiencing certain side effects while taking Cialis.

Other medications, including anti-seizure drugs, may interact with Cialis and cause adverse effects.

  • Anticoagulants
  • Antidepressants
  • Antipsychotics
  • Other medicines or substances

Although there is not a known interaction between Cialis and other medications, some people may experience an increased risk of experiencing certain side effects while taking Cialis.